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Nicolle Domnik PhD
 Nicolle Domnik
Assistant Professor
Contact Info
Botterell Hall

Appointment: Department of Biomedical and Molecular Sciences
Cross-Appointment: Medicine (Respirology)


  • CIHR Banting Postdoctoral Fellow (Medicine/KHSC; 2017-2019)
  • PhD (Physiology, Queen’s; 2015)
  • BHSc (Life Sciences, Queen’s; 2010)

Research Placements:

  • Hospital for Sick Children (Pathology; 2014)
  • University of Tasmania (Zoology; 2012)
  • University of Heidelberg (Intelligent Surgery; 2009)


My background spans basic as well as clinical physiology, centred around autonomic regulation of the cardiopulmonary systems with a specific emphasis on respiratory (patho)physiology. I have been engaged in lectureship since January 2014, contributing to the Life Sciences, Nursing, and Undergraduate Medical curricula at Queen’s University as well as the Interdisciplinary Medical Sciences curricula at the undergraduate and graduate levels at Western University. I am an active member of the CanCOLD Cohort Physiology, Pathophysiology and Imaging Thematic Working Group, European Respiratory Society/European Respiratory Review, and Canadian Institutes of Health Research.

Research Interests:       

Research in the Domnik Lab centers around the intersection of how breathing impacts upon states of physiologic stress, such as exercise and sleep, and vice-versa – how exercise and sleep influence breathing. This is explored in patient populations, including Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA), and across the spectrum of heathy ageing, with recognition for sex-differences and circadian influences.

Current projects include investigating the impact of nocturnal non-invasive ventilation (NIV) therapy on ventilatory drive to breathe in advanced COPD; how the combined occurrence of COPD and OSA alters exercise capacity and motivation; and developing tools and techniques for facilitating data analysis in cardiopulmonary physiology. These projects are undertaken in collaboration with local colleagues in Respirology as well as collaborators from institutions across Canada and internationally. 

Sample Publications:

For up-to-date list, please see PubMed  or Google Scholar

  1. Domnik, N. J., Phillips, D. B., James, M. D., Ayoo, G. A., Taylor, S. M., Scheeren, R. E., ... & O’Donnell, D. E. (2022). Compensatory responses to increased mechanical abnormalities in COPD during sleep. European Journal of Applied Physiology, 122(3), 663-676.
  2. Domnik, N. J., Vincent, S. G., & Fisher, J. T. (2022). Mechanosensitivity of Murine Lung Slowly Adapting Receptors: Minimal Impact of Chemosensory, Serotonergic, and Purinergic Signaling. Frontiers in Physiology, 13.
  3. Domnik, N. J., James, M. D., Scheeren, R. E., Ayoo, G. A., Taylor, S. M., Di Luch, A. T., ... & O’Donnell, D. E. (2021). Deterioration of nighttime respiratory mechanics in COPD: impact of bronchodilator therapy. Chest, 159(1), 116-127.
  4. Domnik, N. J., Torbey, S., Seaborn, G. E., Fisher, J. T., Akl, S. G., & Redfearn, D. P. (2021). Moving average and standard deviation thresholding (MAST): a novel algorithm for accurate R-wave detection in the murine electrocardiogram. Journal of Comparative Physiology B, 191(6), 1071-1083.
  5. Domnik, N. J., Walsted, E. S., & Langer, D. (2020). Clinical utility of measuring inspiratory neural drive during Cardiopulmonary Exercise Testing (CPET). Frontiers in Medicine, 483.