Wednesday April 5th, 2023
1:00pm – 2:00pm
School of Medicine, Room 123A
Dr. Avena C. Ross
Associate Professor
Department of Chemistry
Queen’s University
Investigating the biosynthesis of tambjamines: bacterial alkaloid natural products
Natural Products are molecules produced by living organisms that serve as a means of communication and competition with other organisms. The innate bioactivities of Natural Products have been leveraged for the development of many drug therapies particularly for the treatment of infectious diseases and cancers. The prodiginines and tambjamines comprise a large family of microbially produced bioactive alkaloid Natural Products. They are characterized by a common bipyrrole and subclassified as prodiginines when they contain a third pyrrole or tambjamines with an alkyl amine instead. Despite isolation of a sizeable number of tambjamine molecules from natural sources, only a very small number of these molecules have been correlated with a producing microbe and a biosynthetic gene cluster, thereby limiting our understanding of the biosynthesis of the tambjamine subclass. In this presentation, the genome-guided isolation of several tambjamines will be discussed alongside our work on the biosynthesis of these alkaloids and investigations of several enzymatic steps in the later stages of prodiginine and tambjamine production.
BMED 897 MSc Seminars
Tuesday January 31, 2023
1:00 pm – 2:00 pm
Botterell Hall, Room B139
Richard Nauman
Microbes, Immunity and Inflammation Field
1:00 – 1:30 pm
Investigating the Role of Trained Immunity in Bladder Cancer Progression
Supervisor – Dr. Charles Graham
Julia Barilo
Microbes, Immunity and Inflammation Field
1:30 – 2:00 pm
Characterizing the Innate Immune Response of Alternatively Activated Macrophages to LCMV Infection
Supervisor – Dr. Sam Basta
There are no events available for viewing at this time. Please check back again later, thank-you.
BMED 897 MSc Seminars
Daniella Gilmour
Experimental Medicine Field
Supervisor – Drs. Alan Lomax and Stephen Vanner
Synergistic Effects of Histamine and Proteases in Visceral Hypersensitivity
Tuesday January 24, 2023
1:00 pm – 2:00 pm
Botterell Hall, Room B139
BMED 897 Student Symposium
Tuesday April 04, 2023
12:30 pm – 2:25 pm
Botterell Hall, Room B139
|
Time |
Speaker |
Seminar Title
|
Supervisor(s) |
|
12:30 pm |
Jayne Dent BCB |
Functional Testing of Chromosome-19 microRNA Cluster (C19MC) in Metastatic Skin Cutaneous Melanoma |
Andrew Craig |
|
12:45 pm |
Jocelyn Lee BCB |
Probing Structure-Function Relationships of an Ice Nucleation Protein Using a Droplet Freezing Assay |
Peter Davies |
|
1:00 pm |
Dylan Falconer BCB |
Biosynthesis of Bacterial Polysaccharides |
Inka Brockhausen Chris Lohans |
|
1:15 pm |
Leila Tibouti BCB |
Characterizing the Functional Implications of Polyhistidine Polyphosphorylation in Transcription Factors |
Zongchao Jia |
|
1:30 pm |
|
10 Minute Break |
|
|
1:40 pm |
Lauren Brown TDDHT |
Investigating the Impact of Valproic Acid on Placental Development in CD-1 Mice |
Louise Winn |
|
1:55 pm |
James Cornwell EM |
Investigating the Novel Role of hERG as an ITIM-Containing Fcy Receptor |
Shetuan Zhang
|
|
2:10 pm |
Sahil Sachdev EM |
The Role of Microbial Metabolites in the Regulation of Satiety Signalling
|
Alan Lomax David Reed |
|
|
|
Seminar Attendance & Rubric Evaluations Submission |
|